C O N T E N T SSee AlsoDescriptionElevated levels of Galectin 3, hGal-3 are found in a wide range of neoplasms, and expression was shown to be associated in some tumor cell systems with metastases. Galectin-3 has been shown to be involved in cell adhesion and activation of immune cells and plays a significant role in cell to extracellular matrix interactions. High levels of galectin-3 in metastatic cancer cells suggest an impact on metastasis formation.
Galectin 3 Galectin 3 and the blood group precursor and tumor associated carbohydrate T antigen play a leading role in docking breast and prostate cancer cells onto endothelium. Importantly, T antigen-bearing glycoproteins are also capable of mobilizing galectin-3 to the surface of endothelial cells, thus priming them for harboring metastatic cancer cells. Galectin 3 mediates genistein-induced G(2)/M arrest and inhibits apoptosis. It has a binding capacity for various glycoconjugates including IgE. AbstractsThe role of galectin-3 in endocytosis of advanced glycation end products and modified low density lipoproteinsBiochem Biophys Res Commun. 2001 Feb 2;280(4):1183-8. Zhu W, Sano H, Nagai R, Fukuhara K, Miyazaki A, Horiuchi S.
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