Genomics

See Also

• ApoE
• Apolipoprotein A-I (APOA1), Apolipoprotein A-4 (APOA4),
• Apolipoprotein E (APOE)
• Cardiovascular disease, ABO blood groups and secretor status
• Cholesterol and triglyceride levels, ABO blood groups and secretor status
• INSIG2 (Insulin Induced Gene 2)

Description

• Gene type: protein coding
• Chromosome: 7; Location: 7q36
• Gene name: INSIG1
• Gene description: insulin induced gene 1
• Organism: Homo sapiens
• Gene aliases: CL-6; MGC1405

Summary

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Discussion

INSIG1 and p41-Arc are known to be involved in cellular differentiation and morphology, respectively, and it was suggested that their reduced expressions might be involved in gastric cancer development or progression. [1]

INSIG-1 plays a role in regulating cholesterol concentration in human cells. [2]

INSIG-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes.[3]

Links