Polyflora® O


ABO specific probiotic formula with ABO friendly prebiotics


Polyflora ABO was especially designed to deliver therapeutic levels of blood type friendly bacteria (probiotics) and growth media (prebiotics) specific for each ABO type.

Highlights of Polyflora® O include:

Streptococcus thermophilus

  • As a beneficial flora for type O, S. thermophilus may help reduce diarrhea associated with dysbiosis and H. pylori. (29)
  • Supports immune modulation
  • Supports the breakdown of lactose in dairy
  • Synthesizes folate

Lactobacillus rhamnosus

  • One of the most researched probiotics, L. rhamnosus has been shown to improved constipation and or diarrhea in adults and children. (28)
  • Natural inhabitant of urinary and vaginal flora.
  • Supports cholesterol metabolism and healthy cholesterol levels, which may explain its ability support healthy weight management. (22)

Banana fruit powder

  • Bananas fruit contains a unique oligosaccharide compliant with the blood type O antigen that also acts as a prebiotic for flora.
  • Promotes short-chain fatty acid production by colonic bacteria 

Chicory root

  • Chicory contains inulin, a prebiotic powder to support a healthy bacterial community.
  • The content of inulin is concentrated in chicory root, allowing a significant serving of inulin in a minimal dose.


Larch arabinogalactan

  • Larch is resistant to digestion in the upper intestinal tract, which allows it to travel to the colon and lower GI where it can then be fermented by bacteria and serve as a substrate and food source for commensal bacteria. 

Saccharomyces boulardii

  • Helps prevent antibiotic induced bacterial overgrowth. (32)
  • Protects against other pathogenic bacteria



The term “Probiotic” means “in favor of life”. It was coined in 1910, by the Russian physician Metchnikoff, who promoted a theory of longevity, which associated prolonged life and improved health with decreased gastrointestinal toxicity. He suggested that aging is a process mediated by chronic exposure to putrefactive intoxication caused by imbalances in intestinal bacteria and that this process could be halted by the routine ingestion of lactic acid bacteria and their “fermented” (“cultured”) food products.

Almost 90 years have passed since he introduced these radical ideas; however, in many respects his ideas have been proven to be true. Consumption of lactic acid bacteria, or food cultured or fermented with these friendly microorganisms does extend life in animal experiments and does dramatically reduce a wide range of intestinal metabolites, such as indoles, polyamines, cresols, nitrates/nitrites, and carcinogens which we now know are counterproductive to good health.

Even using strains of friendly bacteria that have a great ability to survive digestion and colonize your digestive tract, there is a tendency for a gradual decline in the quantity of these bacteria over time. This decline is substantially worsened with stress, poor dietary choices, antibiotics and other drugs. In today’s world, with all of its modern pressures, the ability to maintain an optimal intestinal microbial balance is almost always taxed. It has also actually been estimated that we consume 1 million times LESS healthy bacteria in our diet today than our ancient ancestors consumed.

Saccharomyces boulardii
Chicory Root
Larch arabinogalactan
Streptococcus thermophilus
Lactobacillus rhamnosus

TABLE 1: Key agents in Polyflora® O.


Blood type antigens are actually prominent in the digestive tract and, in about 80% of individuals (secretors), are also prominent in the mucus that lines the digestive tract. Because of this, many of the bacteria in the digestive tract actually use ABO antigens as a preferred food supply.

In fact, blood group specificity is common among intestinal bacteria with almost 1/2 of strains tested showing some blood type A, B, or O specificity. To give you an idea of the magnitude of the blood type influence on intestinal microflora, it has been estimated that someone with blood type B will have up to 50,000 times more of some strains of friendly bacteria than either blood type A or O individuals. Second, some strains of beneficial bacteria actually can have lectin-like hemagglutinin activity directed against your blood type.

Friendly bacteria restore intestinal balance, which result in:

  • The prevention of adherence of unwanted microorganisms
  • The production of a wide array of antibacterial and antifungal compounds
  • Improved resistance against bacteria like E.coli & Salmonella. and H. pylori


Friendly bacteria enhance immunity by:

  • Promoting improved anti-viral immune system function
  • Increasing natural killer (NK) cell activity
  • Increasing secretory IgA (S-IgA) antibodies
  • Producing nitric oxide
  • Modulating cell mediated immune response
  • Activating the reticuloendothelial system
  • Promoting a more balanced production of cytokines
  • Promoting resistance against some autoimmune processes
  • Evoking anti-Tn antibodies
  • Decreasing IgE-mediated responses
  • Enhancing immune system response to administered vaccines
  • Mediating against radiation-induced depression in white blood cells


In many respects, friendly bacteria can be thought of as having “adaptogenic” effects on the immune system. They appear to modulate the nonspecific immune response differently in healthy and hypersensitive subjects. This is seen as an immuno-stimulatory effect in healthy subjects, and as a down- regulation of immunoinflammatory responses in hypersensitive subjects.

Friendly bacteria promote detoxification by:

  • Inactivating and eliminating carcinogens
  • Decreasing mutagenic compounds
  • Decreasing activity of nitroreductase and azoreductase
  • Decreasing activity of B-Glucuronidase, B-Glucosidase
  • Decreasing activity of ornithine decarboxylase
  • Decreasing activity of tryptophanase
  • Decreasing activity of neuraminidase and mucinase
  • Decreasing levels of polyamines, cresols and indoles
  • Decreasing ammonia
  • Decreasing levels of nitrates and nitrites
  • Enhancing liver function and promoting elimination of bile acids
  • Enhancing cholesterol metabolism


Friendly bacteria promote healthy digestion by

  • Normalizing stool volume and regularity
  • Producing digestive enzymes that help digest proteins, carbohydrates, and fibers
  • Decreasing intestinal permeability
  • Decreasing food sensitivities
  • Decreasing lactose intolerance
  • Decreasing intestinal inflammation


Friendly bacteria enhance bioavailability of nutrients by

  • Alleviating symptoms of malabsorption
  • Increasing the absorption of zinc, calcium, iron, copper, manganese, and phosphorous
  • Increasing the production of vitamins B1, B2, B3, B5, B6, B12, A, K, folic acid, biotin, and tocopherols


2 capsules, 2 times daily.


This product was introduced by NAP in 2001 after first being specifically designed for use in my clinic.


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