TypeZyme A

The chemical process of digestion depends upon enzymes to break down complex food components (e.g., polysaccharides, fats, and proteins) into their absorbable forms (e.g., monosaccharides, fatty acids, and amino acids) for bodily use. These enzymes are secreted by cells or glands in the gastric mucosa as well as directly from exocrine glands including the salivary gland, pancreas, gallbladder, and liver. [1] Impediments to chemical digestion can lead to maldigestion, malabsorption, changes to the pH of the GI tract, and hence alterations to the microbiome.

Supplementing with digestive enzymes has been shown to improve digestion and restore balance when chemical digestion has been disrupted. This can lead to improvements in gastroesophageal reflux, dysbiosis, dyspepsia, and even inflammatory GI disorders. [2]

Typezyme formulas have been designed by Dr. Peter J. D’Adamo with blood type specificity in mind. His identification of blood-type-associated digestive patterns guided formulations that optimize nutrient breakdown and assimilation while reducing symptoms of maldigestion for each type.

Variations between the blood types regarding the production and array of digestive enzymes have been extensively reported in the medical literature. In fact, the level of certain digestive enzymes can vary by as much as a four-fold difference when one considers just   ABO blood type and secretor status. That’s why I thought it was important to develop a line of enzymes that took the strengths and weaknesses of each blood type into account. Now after over two years of development and testing, we’re ready to release these new TypeZyme formulas.

As with all DPN. Products, these formulas as assayed for potency, and screened for heavy metals and unwanted microbial activity. The individual ingredients have been sourced from around the world and selected by our technical team for maximum bioactivity. I believe these are the best digestive support formulas available.

Adequate stomach acid levels, critical for initiating the breakdown of animal protein, are often lacking in blood type A. This formula uses betaine HCL as a gentle assist to the first stage of protein breakdown. Betaine is a substance that's made in the body. It's involved in liver function, and cellular reproduction, while also helping the body metabolize an amino acid called homocysteine – an added plus for type A, due to the link between homocysteine and artery disease, a major risk factor for this blood type.

To support the second stage of protein digestion, TypeZyme A employs two protein-busting enzymes, a standard protease, and a special acid-stable form of protease as well. Because type A often has the lowest levels of critical intestinal enzymes known as phosphatases, I’ve included lipase in the formula to assist in fat breakdown. Finally, the formula rounds out with a synergistic dose of the plant enzyme bromelain, which helps condition the gut and acts like a gentle detergent throughout the digestive system.

TypeZyme A is formulated with the combination of digestive molecules necessary for optimal digestion in blood type A’s.

• Betaine HCL- Betaine HCL re-acidifies the stomach. This improves the digestion of food, alters the gastric environment for beneficial microbe growth, and reduces symptoms associated with hypochlorhydria such as GERD. [4] This also reduces homocysteine, which is linked to coronary artery disease, a major risk factor for blood type A. [5]
• Bromelain- Bromelain is found in the stem and fruit of the pineapple (Ananas comosus) and is a known anti-inflammatory and digestive aid in instances of pancreatic insufficiency and other intestinal disorders. [6]
• Acid Stable Protease- This breaks proteins into amino acids in the acidic environment of the stomach. Protein maldigestion can lead to putrefaction in the gut and the production of toxic metabolites that are both inflammatory and disruptive to the microbiome. [7] Proteases are largely responsible for keeping the small intestine free from parasites (including bacteria, yeast, protozoa, and intestinal parasites) 
• Lipase- Lipase is typically secreted by the pancreas to break down lipids. Supplementation with lipase has been shown to correct pancreatic insufficiencies and reduce bloating and discomfort following high-fat meals. [8,9]

Individuals with blood type A have statistically lower hydrochloric acid levels in the stomach as compared to other groups. [cite] Studies have shown that the ability to secrete stomach acid decreases with age. [3] This predisposes Type A’s to insufficient protein and fat digestion and other symptoms of hypochlorhydria such as belching, gas, bloating, indigestion, gastroesophageal reflux, bacterial/fungal overgrowth, and/or nutrient deficiencies (specifically vitamins A, D, E, K). 

 TypeZyme A is useful for symptoms associated with maldigestion such as:

• Acid Reflux
• Indigestion
• Bloating, Belching, Flatulence
• Diarrhea or Constipation
• Undigested food in stool
• Acne
• Hair Loss
• Food Sensitivities
• Nutrient Deficiencies

A low gastric acidity level can also create an environment optimal for specific bacterial infections. Restoring gastric acid, and effectively lowering the pH of the stomach, has been shown to prevent the overgrowth of organisms such as Helicobacter pylori, which is widely associated with gastritis, peptic ulcers, and gastric cancer. [9]

1. Mills, J.C., & Stappenbeck, T.S. (2014). Gastrointestinal disease. In G.D. Hammer & S.J. McPhee (Eds.), Pathophysiology of disease: An introduction to clinical medicine (pp. 333-383). Columbus, OH: McGraw-Hill Education.
2. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A., & Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current drug metabolism, 17(2), 187–193. https://doi.org/10.2174/138920021702160114150137
3. Bender, A.D. (1968), EFFECT OF AGE ON INTESTINAL ABSORPTION: IMPLICATIONS FOR DRUG ABSORPTION IN THE ELDERLY. Journal of the American Geriatrics Society, 16: 1331-1339. https://doi.org/10.1111/j.1532-5415.1968.tb02776.x
4. Guilliams, T. G., & Drake, L. E. (2020). Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?. Integrative medicine (Encinitas, Calif.), 19(1), 32–36.
5. McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med. 2013 Mar;12(1):20-5. doi: 10.1016/j.jcm.2012.11.001. PMID: 23997720; PMCID: PMC3610948.
6. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1998;22:191–203.
7. Dallas, David & Sanctuary, Megan & Qu, Yunyao & Haghighat Khajavi, Shabnam & Zandt, Alexandria & Dyandra, Melissa & Frese, Steven & Barile, Daniela & German, Bruce. (2015). Personalizing Protein Nourishment. Critical reviews in food science and nutrition. 57. 10.1080/10408398.2015.1117412. 
8. Delhaye, M., Meuris, S., Gohimont, A. C., Buedts, K., & Cremer, M. (1996). Comparative evaluation of a high lipase pancreatic enzyme preparation and a standard pancreatic supplement for treating exocrine pancreatic insufficiency in chronic pancreatitis. European journal of gastroenterology & hepatology, 8(7), 699–703.
9. Park, S. Y., & Rew, J. S. (2015). Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?. Gut and liver, 9(4), 433–434. https://doi.org/10.5009/gnl15206
10. Waldum, H. L., Kleveland, P. M., & Sørdal, Ø. F. (2016). Helicobacter pylori and gastric acid: an intimate and reciprocal relationship. Therapeutic Advances in Gastroenterology, 836–844. https://doi.org/10.1177/1756283X16663395