TypeZyme O


ABO specific digestive enzyme complex


The chemical process of digestion depends upon enzymes to break down complex food components (e.g., polysaccharides, fats, and proteins) into their absorbable forms (e.g., monosaccharides, fatty acids, and amino acids) for bodily use. These enzymes are secreted by cells or glands in the gastric mucosa as well as directly from exocrine glands including the salivary gland, pancreas, gallbladder, and liver. [1] Impediments to chemical digestion can lead to maldigestion, malabsorption, changes to the pH of the GI tract, and hence alterations to the microbiome.

Supplementing with digestive enzymes has been shown to improve digestion and restore balance when chemical digestion has been disrupted. This can lead to improvements in gastroesophageal reflux, dysbiosis, dyspepsia, and even inflammatory GI disorders. [2]

Typezyme formulas have been designed by Dr. Peter J. D’Adamo with blood type specificity in mind. His identification of blood-type-associated digestive patterns guided formulations that optimize nutrient breakdown and assimilation while reducing symptoms of maldigestion for each type.

Variations between the blood types regarding the production and array of digestive enzymes have been extensively reported in the medical literature. In fact, the level of certain digestive enzymes can vary by as much as a four-fold difference when one considers just   ABO blood type and secretor status. That’s why I thought it was important to develop a line of enzymes that took the strengths and weaknesses of each blood type into account. Now after over two years of development and testing, we’re ready to release these new TypeZyme formulas.

As with all DPN. Products, these formulas as assayed for potency, and screened for heavy metals and unwanted microbial activity. The individual ingredients have been sourced from around the world and selected by our technical team for maximum bioactivity. I believe these are the best digestive support formulas available.



  • Amylase- This enzyme is often the first step in digestion as it is secreted by salivary glands and again in the pancreas. Amylase aids with the metabolism of sugars and improves intestinal permeability. [3]
  • Cellulase- Cellulase breaks down cellulose which is the main constituent of plant fiber and roughage. This is also helpful in breaking apart microbial biofilms which can contribute to dysbiosis and inflammation. [5] This enzyme also releases antioxidants that are otherwise trapped in food sources. [6]
  • Ox Bile- Ox bile has an ancient history of use in Traditional Chinese Medicine in the treatment of jaundice and intestinal parasites. It was also used to reduce hemorrhoids due to astringent properties. Modern use of ox bile has shown efficacy in the treatment of steatorrhea as it is a fat emulsifier.[7]
  • Pancreatin- This is a blend of enzymes typically created in the pancreas that aid in the digestion of proteins, sugars, and fats. This reduces typical postprandial symptoms of fatty meals including gas, bloating, and fullness. [8]

Ox Bile

TABLE 1: Key agents in TypeZyme O.


Naturopathic approaches to digestion focus on improving physiologic function via the promotion of enzymes rather than the suppression of secretions. Many common pharmaceutical prescriptions and over-the-counter drugs work to neutralize stomach acid or block its release from the gastric mucosa which may lower symptoms but also alter the gut microbiome and lead to decreased digestive function and nutrient absorption.

Normally a digestive powerhouse, type O can easily trip up with its breakdown and metabolism of carbohydrates.  Thus, while TypeZyme O provides general protein and fat breakdown support via the inclusion of ox bile and bovine pancreatin, the main focus of the formula is to enhance carbohydrate breakdown, a critical function for this blood type, and whose improper function typically results in bloating, dysbiosis, and weight gain.  It does this by synergizing two critical enzymes needed for proper carbohydrate metabolism: amylase and cellulase. 

The amylase enzyme helps the body to break down carbohydrates. It is normally made by the pancreas and salivary glands in the mouth. Cellulase aids in the breakdown of cellulose, the main constituent of plant fiber and roughage. Cellulase also helps in the breakdown of harmful microbial biofilms, which can lead to increased inflammation in this blood type. Finally, cellulase helps to release healthy antioxidant compounds otherwise trapped in the food. As with all the TypeZyme formulas, TypeZyme O rounds out with a synergistic dose of the plant enzyme bromelain, which helps condition the gut and acts like a gentle detergent throughout the digestive system.

Typezyme O is useful for symptoms associated with maldigestion such as:

  • Acid Reflux
  • Indigestion
  • Bloating, Belching, Flatulence
  • Diarrhea or Constipation
  • Undigested food in stool
  • Acne
  • Hair Loss
  • Food Sensitivities
  • Nutrient Deficiencies

A low gastric acidity level can also create an environment optimal for specific bacterial infections. Restoring gastric acid, and effectively lowering the pH of the stomach, has been shown to prevent the overgrowth of organisms such as Helicobacter pylori, which is widely associated with gastritis, peptic ulcers, and gastric cancer. [9]



2 capsules with lunch and dinner


This product was introduced by NAP in 2023.


  1. Mills, J.C., & Stappenbeck, T.S. (2014). Gastrointestinal disease. In G.D. Hammer & S.J. McPhee (Eds.), Pathophysiology of disease: An introduction to clinical medicine (pp. 333-383). Columbus, OH: McGraw-Hill Education.
  2. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A., & Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current drug metabolism, 17(2), 187–193.
  3. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019 Aug;68(8):1516-1526. doi: 10.1136/gutjnl-2019-318427. Epub 2019 May 10. PMID: 31076401; PMCID: PMC6790068.
  4. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1998;22:191–203.
  5. Loiselle M, Anderson KW. The use of cellulase in inhibiting biofilm formation from organisms commonly found on medical implants. Biofouling. 2003 Apr;19(2):77-85. doi: 10.1080/0892701021000030142. PMID: 14618691.
  6. Chen, D., Shi, J. & Hu, X. Enhancement of polyphenol content and antioxidant capacity of oat (Avena nuda L.) bran by cellulase treatment. Appl Biol Chem 59, 397–403 (2016).
  7. Wang, D. Q., & Carey, M. C. (2014). Therapeutic uses of animal biles in traditional Chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review. World journal of gastroenterology, 20(29), 9952–9975.
  8. Suarez F, Levitt MD, Adshead J, Barkin JS. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal. Dig Dis Sci. 1999 Jul;44(7):1317-21. doi: 10.1023/a:1026675012864. PMID: 10489912.
  9. Waldum, H. L., Kleveland, P. M., & Sørdal, Ø. F. (2016). Helicobacter pylori and gastric acid: an intimate and reciprocal relationship. Therapeutic Advances in Gastroenterology, 836–844.

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