NP035 Tranquility BaseTAGS: ADRENAL SUPPORT | BRAIN | ENERGY PRODUCTION | IMMUNITY | STRESS/ HPA AXIS Natural calmative for occasional tension INTRODUCTION Occasional stress and anxiety are natural functions of life, but when balanced with appropriate amounts of relaxation, meditation, and exercise, occasional stress can be taken in stride and can actually support health and well-being. Sometimes, however, the scale tips too far; we may not get that daily relaxation time, and we can find a bit more of an imbalance than we’re used to. Tranquility Base is designed for times like these to help provide mental and physical relaxation, while decreasing occasional stress and anxiety. Only the best researched herbs have been included. This unique formula can be used by men and women of all ABO blood types. DESCRIPTION/ BACKGROUND Tranquility Base comprises four synergistic ingredients. GABA (Gamma-Aminobutyric Acid). GABA in the central nervous system, is the primary inhibitory neurotransmitter. It is synthesized in the brain by the decarboxylation of glutamate. (1,2) GABA exerts anticonvulsant, sedative, and anxiolytic effects at the cellular level. (1,2) L-Theanine. L-Theanine is the major amino acid found in green tea and appears to be a relaxant that increases alpha-waves, producing mental and physical relaxation while decreasing stress and anxiety, without inducing drowsiness. (3-5) Theanine has historically been used for its relaxing and anti-anxiety effects. It’s thought that theanine might work for anxiety by increasing levels of GABA and serotonin. (6) Lemon balm (from Melissa officinalis). The applicable part of Lemon balm is the leaf and leaf oil. Lemon balm seems to have sedative, antioxidant, and antiviral effects. (7-10) Lemon balm contains citronella, neral, and geranial monoterpenoid aldehydes, flavonoids and polyphenolic compounds (including rosmarinic acid) and monoterpene glycosides. These substances may contribute to the behavioral effects of lemon balm dried leaf and essential oil. (8) Some research suggests lemon balm might have acetylcholine receptor activity with both nicotinic and muscarinic binding properties. (8) Clinical research suggests that lemon balm induces a calming effect and reduces alertness. (8) Chamomile Leaf Standardized Extract (from Matricaria recutita, Standardized to 1.2% Apigenin). The active constituents of Chamomile include quercetin, apigenin, and coumarins, and the essential oils matricin, chamazulene, alpha bisaboloid and bisaboloid oxides. (11) Although the constituent(s) responsible for the sedative activity of German chamomile are unclear, some preliminary research suggests that apigenin can bind to gamma-aminobutyric acid (GABA) receptors. GABA receptors are the primary receptor sites of benzodiazepines in the central nervous system. However, other research suggests that apigenin doesn’t affect GABA receptors and that other constituents of German chamomile are responsible for the sedative activity. (12,13)
TABLE 1: Key agents in Tranquility Base.
TYPICAL DOSAGE 1 capsule 1-2 times daily, or as directed by physician PRODUCT HISTORY This product was introduced by NAP in 2004 after first being specifically designed for use in The D’Adamo Clinic. REFERENCES
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