Histona Ulterior


To help support circulatory and metabolic health


Histona “Ulterior” is the new and improved reformulation of our best-selling formula “Histona.” The new product increases the dosage of Magnolia bark and supplies three additional herbal synergist factors, Dan Shen (Salvia miltiorrhiza), Chinese Skullcap (Scutellaria baicalensis) and Betaine HCL. It is designed to provide a broad spectrum of cell normalization support, stress relief and anti-oxidant protection.


Magnolia Bark Extract (from Magnolia officinalis).  Magnolia is a traditional Chinese medicine used since ancient times for tension, fatigue and digestive disturbances caused by emotional stress. Recent studies have shown that the two main components of magnolia, the anti-oxidants honokiol and magnolol, have a wide variety of beneficial effects on stress, immunity and metabolism.

Stress relief: The honokiol in Magnolia bark has been shown to possess mild but non-sedating anxiolytic (anti-anxiety) activity at low doses. Magnolia can help to relieve stress symptoms without causing drowsiness. Newer claims are emerging, however, that link magnolia’s anti-stress benefits with control of cortisol, the body’s primary stress hormone. Cortisol imbalance has been associated with obesity, diabetes, osteoporosis, memory problems, and suppressed immune function.

Anti-oxidant and brain health: The magnolol and honokiol components of Magnolia officinalis are one thousand times more potent than alpha-tocopherol (vitamin E) in their antioxidant activity. Other research groups have shown both magnolol and honokiol to possess powerful “brain-health” benefits via their actions in modulating the activity of various neurotransmitters and related enzymes in the brain.

Metabolic effects: Magnolia’s effect on cortisol is just one of the ways that this amazing herb can help to enhance healthy metabolic and immune function. Magnolia has also been shown to reduce allergic reactions and the herb is also an effective inhibitor of AGEs (Advanced Glycation Endproducts).

Chinese Skullcap Root extract (from Scutellaria biacalensis).  Chinese skullcap root has a cell-regulating effect and encourages efficient removal of metabolically compromised cells, which have become dysfunctional, either through age or malformation. It’s flavonoid is a member of the mint family and has long been used in traditional Chinese herbal medicine, as a digestive aid, and to normalize an over-active digestive system. Scutellaria has been shown to decrease inflammatory cytokine production from human mast cells (immune system hormones which ramp up inflammation). Scutellaria also has a cell-regulating effect; encouraging the body to more efficiently remove cells which have become dysfunctional, either through age or malformation. (2)

Salvia miltiorrhiza Root.  Salvia has been used to support healthy heart function as well as for its anti-inflammatory properties. Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza, which is a traditional herbal medicine that is used to treat cardiovascular diseases. Recent studies showed that Tanshinone IIA possesses cytotoxic activity against many kinds of human carcinoma cell lines, induces differentiation and apoptosis and inhibits invasion and metastasis of cancer cells. Its mechanisms are thought to inhibit DNA synthesis and proliferation of cancer cells, regulating the expression of genes related to proliferation, differentiation, and apoptosis, inhibiting the telomerase activity of cancer cells, and changing the expression of cellular surface antigen. (3)

Betaine HCl.  Betaine hydrochloride is a gastric activating cofactor. Betaine hydrochloride is a stomach-acidifying, important cofactor and also a digestive enzyme. (4) Betaine hydrochloride is a non-essential nutrient and a source of hydrochloric acid, a naturally occurring chemical in the stomach that helps digest food by breaking up fats and proteins. In particular, Betaine HCL is necessary for adequate absorption of protein, calcium, vitamin B12 and iron. It is also known as hydrochloric acid and stomach acid. The low pH of the stomach’s hydrochloric acid also destroys ingested bacteria and microorganisms.

Salvia miltiorrhiza (Danshen)
Skullcap (Scutellaria baicalensis)
Magnolia (Magnolia officinalis)

TABLE 1: Key agents in Histona Ulterior.



One (1) capsule twice daily with meals as a dietary supplement.



  2. Gao Z, Huang K, Xu H. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacol Res. 2001; 43(2):173-178.
  3. Ai Zheng. 2003 Dec;22(12):1363-6.
  4. Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. Vol 1. 2nd ed. Churchill Livingstone; 1999:462-466. 

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