Nutraceutical formula designed to optimize cellular energy


Automobiles burn gasoline for energy. Humans burn sugars. And like a car with a poor combustion mixture (too much fuel/not enough air) problems inevitably result with the motor, and eventually there is a loss of horsepower. Scientists are now beginning to understand the elegant feedback mechanisms that our bodies use to perform this tricky balancing act. Much of the responsibility lies with a powerful molecule known as AMPK. It's so important, it has been given the nickname the fuel gauge of the cell. Just like the fuel gauge of a car, AMPK monitors and helps control the amount of energy available to drive the cell's metabolism. Thus, maintaining healthy AMPK function is essential to having a well-tuned metabolism.

 Utilizing cutting-edge insight into molecular biology, Dr. Peter D'Adamo formulated GlycoSynergy, a unique formula designed to support the healthy function of AMPK. He has found that patients on the GlycoSynergy protocol show healthy blood sugar regulation, an increase in muscle mass, normalized cellular energy production, and a metabolism working at optimal levels, especially when combined with proper diet and exercise. Maintaining healthy function of AMPK also improves many of the cellular systems involved in waste removal. This has important significance with regard to anti-aging, as the accumulation of cellular waste products is a well-recognized sign of the aging process. Almost every bit of research on anti-aging strategies, from calorie restriction to exercise, finds its basis in its ability to enhance these two important functions.



GlycoSynergy comprises seven synergistic botanicals and nutrients.

Guarana Seed (from Paullina cupana)

Paullina cupana is native to the Amazon region of South America and has been utilized by the people of Brazil and Columbia as a mental stimulant for centuries. This plant is a climbing evergreen vine that has been shown in human studies to reduce fatigue, stress, anxiety, and depression symptoms following chemotherapy treatments of women with breast cancer (1). This is primarily due to the seeds of P. cupana having large amounts of methylxanthines. These constituents are very sought after for metabolic control via its thermogenesis properties (2). The seed of P. cupana are being used in combination with Salix Alba to increase the effects of the berberine alkaloids found in the other medical plants in this formula.

Berberine HCL (from Berberis aristata)

Berberine is an isoquinoline alkaloid found in B. aristata for its main use of activating adenosine monoadmine phophotase kinase (AMPK). Berberine has been shown to have many cellular effects on humans and animals. This chemical isolate from B. aristata has been shown to have anti-diabetic properties via working on insulin resistance. Berberine has also been shown to improve metabolic rates, increase GLUT4 translocation, and reduce lipid accumulation all via the modulation of AMPK (3).

White Willow Bark (Salix alba)

Salix alba is a synergistic botanical that facilitates activation of the AMPK gene. Salicylate acids can be found in Salix alba and it’s these constitutes that stimulate the AMPK gene that then informs the cell to start the metabolic process (6).

Coleus forskohlii Root

Coleus forskohliiis has been sown to help maintain current weight and to mediate weight gain in subjects (7).

Coptis chinensis rhizome

Coptis chinensis rhizomehas been used for over 2000 years in the Traditional Chinese formula Tang-Min-Ling. C. chinensis has been shown to regulate glucose metabolism in patients with Type II Diabetes Mellitus. Within a new investigation of the Tang-Min-Ling formula was shown to have effects on serum glucose, lipid, and leptin levels, via improving AMPK and GLUT4 regulatory genes (4). In another animal study C. chinensis decreased fasting glucose levels. The berberine in C. chinensisdecreases the amount of cellular oxygen and thus decreases the production of adenosine triphosphate (ATP). This suggests that berberine inhibits gluconeogenesis in the liver thus improving fasting glucose levels (5). 

Gynostemma pentaphyllum

Gynostemma pentaphyllumis an ancient Chinese medical herb used an alternative to Ginseng. Modern research has emerged showing more beneficial uses from this plant other than its long known effects on fatigue. There are two main beneficial constituents in G. pentaphyllum, which are categorized into the saponin family. These saponins (2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside and 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside) have been found to activate AMPK. Another interesting aside is that these two saponins increase b-oxidation and glucose uptake via Glut4 (8).

Coenzyme Q10

Coenzyme Q10, also known as CoQ10, is a vitamin-like chemical that is found in most cells in our body, especially in the heart. It has antioxidant properties, which the body uses to generate ATP, a storage form of energy. CoQ10 has been found to reduce oxidized low-density lipoprotein (ox-LDL) accumulation in human endothelial cells. This process is via modulation of AMPK, which is a negative regulator of NADPH oxidase (9).


Salix alba (willow)
Co-enzyme Q10
Coleus Forskohlii
Coptis rhizome

TABLE 1: Key agents in GlycoSynergy.


GlycoSynergy's main use is to stimulate the AMPK gene. This gene is used to suppress the mammalian target of rapamycin (mTOR). When low ATP levels are present in cells, AMPK becomes activated to reduce the mTOR level. When mTOR levels are elevated it has a number of biological effects including: translation of mRNA via the phosphorylation of downstream targets suppression of autophagy, ribosome biogenesis, and activation of transcription leading to mitochondrial metabolism or adipogenesis. Aberrant mTOR signaling is involved in many disease states including cancer, cardiovascular disease, and metabolic disorders.


Typical dose is 1 capsule, 2 times daily between meals


This product was introduced by NAP in 2014 after being specifically designed for use at the Center of Excellence in Generative Medicine.


  1. Campos, M., Riechelmann, R., Martins, L., Hassan, B., Casa, F., & Giglio, A. (2011). Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy. THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 505-512. doi:10.1089/acm.2010.0571
  2. Rodrigues, M., Alves, G., Lourenco, N., & Falcao, A. (2012). Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats. Evidence-Based Complementary and Alternative Medicine, 2012, 1-10. doi:Article ID 428560
  3. Lee, Y., Kim, W., Kim, K., Yoon, M., Cho, H., Shen, Y., . . . Kim, J. (2006). Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes, 55(8), 2256-2264.
  4. Zhen, Z., Chang, B., Li, M., Lian, F., Chen, L., Dong, L., . . . Tong, X. (2011). Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats. The American Journal of Chinese Medicine, 39(1), 53-63.
  5. Xian, X., Yan, J., Shen, Y., Tang, K., Yin, J., Zhang, Y., . . . Wend, J. (2011). Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLOS ONE, 6(2). doi:10.1371/journal.pone.0016556.
  6. Hardie, D., Ross, F., & Hawley, S. (2012). AMP-activated protein kinase: A target for drugs both ancient and modern. Chemistry and Biology, 19(10), 1222-1236. doi:10.1016/j.chembiol.2012.08.019
  7. Henderson, S., Magu, B., Rasmussen, C., Lancater, S., Kerksick, C., Smith, P., . . . Kreider, R. (2005). Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. Journal of the International Society of Sports Nutrition, 2, 54-62. doi:10.1186/1550-2783-2-2-54
  8. Nguyen, P., Gauhar, R., Hwang, S., Dao, T., Park, D., Kim, J., . . . Oh, W. (2011). New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorganic and Medicinal Chemistry, 19(21), 6254-6260. doi:10.1016/j.bmc.2011.09.013
  9. Tsai, K., Chen, L., Chiou, S., Chiou, G., Chen, Y., Chou, H., . . . Kao, C. (2011). Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway. Molecular Nutrition and Food Research, S227-S240. doi:10.1002/mnfr.201100147


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