Membrosia Fluidizer

The circle of life of cells is as complex as it is simple. The cell links molecular energy and matter into a type of intelligence that drives the tissues and organs. The cell membrane is comprised of two layers of fats and phospholipids. This duality allows the cell to maintain and balance both internal and external water levels allowing cells and molecules to move more efficiently.

Membrosia Fluidizer contains a unique blend of the cellular-supporting nutrients Flaxseed oil, Walnut Oil, Black Cumin Oil, Perilla Seed Oil and Cod Liver Oil.

Flaxseed Oil.  Flaxseed Oil is expressed from the oil-rich seeds of the blue-flowering, common flax plant, Linum usitatissimum, that is cultivated primarily on the prairies of western Canada. Also known as “linseed oil,” this oil is nature’s richest vegetable source of the essential omega-3 fatty acids that are required for the health of all the body’s systems. (2) Because of the relative paucity of sources of omega-3 fatty acids in the modern diet as a result of the grain-feeding and factory farming of animals for food, Flaxseed Oil is highly recommended as a supplemental source of many of the fats needed for general well being and optimum health. In addition to providing approximately 50% more omega-3 oils than what you could get from taking any other vegetable-based oil, Flaxseed Oil contains omega-6 and omega-9 essential fatty acids, B vitamins, potassium, lecithin, magnesium, fiber, protein, and zinc. (3) The health of every organ system in the body, but especially the cardiovascular and circulatory, immune, reproductive, and nervous systems, as well as the joints, can benefit from regular supplementation with Flaxseed Oil’s many enriching constituents.

Walnut Oil (Juglans regia Oil).  Walnut oil is an excellent source of omega-3 fatty acids, Vitamin E, phytosterols, polyphenols, carotenoids, and other fat-soluble (lipophilic) nutrients. It seems that walnuts also contain small amounts of the sleep-regulating hormone melatonin and may slow cancer growth. (17)

Black Cumin Oil (Nigella sativa).  Cumin seed has been a part of the diet and a popular spice regularly used as a flavouring agent in a number of cultures. Cumin is the dried seed of the herb Cuminum cyminum, a member of the parsley family. (24) The Cumin plant grows to about 1 to 2 feet tall and is harvested by hand. Cumin plays a major role in Mexican, Thai, and Indian cuisines. Cumin is also a critical ingredient of chili powder and is found in achiote blends, adobos, garam masala, curry powder, and baharat. (25)

The phospholipid (PL) composition of black cumin seed oil is one of its key attributes that contribute to cell membrane health, as the cell membrane is composed largely of a double layer of these vital phospholipids. The major individual PL classes in black cumin seed oil were found to be phosphatidylcholine (about 46-48% of total PL) followed by phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol respectively. Phosphatidylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine were isolated in smaller quantities. Researchers at the Institute of Food Chemistry at the Technical University of Berlin have characterized black cumin seed oil as a significant source of cell membrane phospholipids. (26)

From the water-soluble portion of the methanol extract of cumin, which has been used as a spice and medicine since antiquity, monoterpenoid glucosides have been isolated. The main bioactive components in the volatile oil of cumin are cuminal (cuminaldehyde) and safranal (accounting for 32% and 24% respectively in the components identified). The other compounds that are present in at least 1% concentrations are monterpenes, sesquiterpenes, aromatic aldehydes, and aromatic oxides. The constituents present in smaller amounts are terpenes, terpenols, terpenals, terpenones, terpene esters, and other aromatic compounds. (27)

Perilla Seed Oil (Perilla frutescens).  The leaves of Perilla frutescens are one of the most popular garnishes in Japan, used as an antidote for fish and crabmeat allergy or as a food colorant. (32) With a minimum of 50% omega-3 fatty acids, perilla seed oil is one of the richest sources of omega-3 fatty acids found in nature. (33)

The chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds is affected by the method of extraction from the seeds used. In a recent study published in the Journal of Food Science, supercritical carbon dioxide [SC-CO(2)], mechanical press, and solvent extraction methods were compared. The SC-CO(2) extraction and hexane extraction showed significantly higher oil yield than mechanical press extraction. Although the fatty acid compositions in the oils were virtually identical regardless of the extraction methods; the contents of tocopherol, sterol, policosanol, and phosphorus in the perilla oils greatly varied with the extraction methods. The SC-CO(2)-extracted perilla oils contained significantly higher contents of beneficial tocopherols, sterols, and policosanols than the mechanical press-extracted and hexane-extracted oils; which is why we’ve chosen to include the SC-CO(2)-extracted form in Membrosia. Unfortunately, on account of this increased amount of delicate constituents, the SC- CO(2)-extracted oil also has a greatly lower oxidative stability than press-extracted and hexane-extracted oils during storage at high temperatures (60° C). Thus, it’s important that Membrosia Fluidizer be refrigerated after opening to prolong its freshness and quality. (34)

Cod Liver Oil.  The active ingredients in cod liver and other fish oil supplements are essential fatty acids known as omega-3 fatty acids. The primary omega-3 fatty acids found in fish are eicosapentaenoic acid (EPA), primarily known for its cardioprotective effects, and docosahexaenoic acid (DHA), prized for its uniquely supportive effects on the nervous system; including boosts to brain health, memory, intelligence, and mood stability. (39-40) The body converts these essential fatty acids into the beneficial, anti-inflammatory eicosanoids, including prostaglandin-3 (which inhibits platelet aggregation), thromboxane-3, and leukotriene-5. (41) Cod liver oil is derived from the livers of white fish, such as cod and sometimes halibut. In addition to the omega-3 fatty acids found in all fish, cod liver oil contains significant levels of vitamins A and D, which are essential for healthy bone formation and maintenance, vision, and reproductive health. (42-43) Cod liver oil also has a higher ratio of DHA to EPA than fish oils derived from the fat of cold-water fish, making it the fish oil of choice for support of the brain and nervous system.

Rosemary extract, acts as a natural preservative.

Tocopherol (Vitamin E), was added into this formula to act as an antioxidant. (51)

The omega-3 fatty acids found in Flaxseed Oil have been shown to reduce systemic reactivity and can therefore be a crucial dietary component in the prevention of those chronic diseases that are characterized by rampant inflammation, such as heart disease and arthritis. Omega-3 fats appear to be essential for healthy growth and development, as well as particularly important during the maturation of cognitive and behavioral functions. Lignans, highly beneficial polyphenolic phytoestrogens found in many foods, are found in particularly high concentrations in our Flaxseed Oil. These lignans appear to modulate excess growth factor levels in healthy aging, which is associated with increased longevity, and encourage programmed cell death (apoptosis) in cells with damaged DNA or aberrant cellular metabolism. (4)

Regular supplementation with Flaxseed Oil can help increase the body’s production of energy and improve stamina. (5) Flaxseed Oil has been shown to ease weight loss in people afflicted with central obesity. (6) It appears to act by stimulating brown fat cells and increasing metabolic rate, making it easier for people to burn off unwanted fat. (7) Dietary supplementation with Flaxseed Oil also significantly increases calcium absorption, bone calcium, and bone density and may thereby slow the rate of postmenopausal bone loss. (8) Flaxseed lignans can protect the function of the liver via an effect on the activity of gamma-glutamyltranspeptidase (GGT, a key liver enzyme in the use of the powerful antioxidant glutathione for drug and xenobiotic detoxification) that induces an increase in reduced glutathione levels. (9)

Combining Flaxseed Oil with lower doses of chemotherapy can relieve many of chemo’s side effects while providing an equally effective means to stop the development of cancer. (10) An increased ratio of omega-3 to omega-6 fatty acids, such as is found in Flaxseed Oil, may help reduce the prevalence of some allergies. (11) Flaxseed Oil helps prevent atherosclerosis (the accumulation of fatty plaques in the lining of blood vessels that can lead to increased cardiovascular disease risk). (12) Regular Flaxseed Oil consumption also helps fight cardiovascular disease by lowering high blood pressure in individuals suffering from hypertension. (13) It has been shown in multiple studies to aid in the treatment of some cases of depression. (14) Additional reports indicate that Flaxseed Oil may be of use in the treatment of multiple sclerosis. (15) It has also been shown to relieve some of the symptoms associated with Premenstrual Syndrome (PMS) in females. (16)

Walnuts are the best for heart health, according to research from the Department of Chemistry at the University of Scranton in Pennsylvania, because they have more and higher quality antioxidants than other popular nuts. Walnuts have the highest free and total polyphenols. The researchers assessed the efficacy of walnut antioxidants by measuring the ability of the free polyphenol walnut extracts to inhibit the oxidation of lower density lipoproteins (LDL + VLDL)— the so-called “bad cholesterol.” A nut polyphenol, catechin, was measured after binding of three nut extracts to lower density lipoproteins. Walnut polyphenols had the best efficacy among the nuts and also the highest lipoprotein-bound antioxidant activity. (18)

Walnut oil has been shown to raise omega-3 fatty acid blood levels. Ingestion of alpha linolenic acid (ALA), of which walnut oil is one of the richest natural sources, is associated with cardiovascular prevention. In one recent study, 10 volunteers consumed the equivalent of 4 walnuts per day (in addition to their usual diet) for 3 weeks. Researchers found that even that relatively small amount of walnut oil per day significantly increases blood levels, not only of ALA, but also of its longer chain derivative eicosapentaenoic acids (EPA) found mostly in fish oil. The findings of this study indicate that plant ALA in walnut oil favourably affects overall omega-3 status. (19)

Some walnut oil every day may help keep mentally sharp as you age. According to a Tufts University study that studied the effects of diets containing from zero to 9% walnuts. After eight weeks, the subjects on the 2% and 6% walnut diets showed improvements in age-sensitive tests of motor and cognitive skills. The essential fatty acids and polyphenols and other antioxidants in walnuts and walnut oil may benefit neural tissue. Interestingly, more is not better: The subjects on the 9% walnut diet actually did worse on certain memory tests. Thus, it is important to balance walnut oil with other healthy fats, which is why Dr. D’Adamo has formulated the ideal fatty acid balance to maximize cognitive benefits for use in Membrosia. (20)

Researchers at Marshall University School of Medicine in Huntington, West Virginia investigated the effects of a diet containing the equivalent of two ounces of walnuts per day on breast cancer growth and development. A control group was fed a diet without walnut oil. Walnut consumption significantly decreased the number of subjects with at least one tumor, the number of glands containing a tumor, and the size of the tumors. The walnut-rich diet boosted omega-3 fatty acid concentrations, which contributed to the decline in tumor occurrence, although other components of the walnuts contributed as well. (21) Researchers at the University of Texas Health Science Center in San Antonio, Texas, investigated the question of how much melatonin is present in walnuts and whether eating walnuts influences melatonin levels and the total antioxidant status of the blood. After feeding walnuts to their subjects, serum melatonin concentrations were measured using a radioimmunoassay and the “total antioxidant power” of the serum was estimated by using the Trolox equivalent antioxidant capacity (TEAC) and ferric-reducing ability of serum methods. The scientists found that melatonin is present in walnuts and, when eaten, walnuts increase blood melatonin concentrations. They concluded that the increase in blood melatonin levels from the walnuts correlates with an increased antioxidative capacity. (22)

Hyperlipidemia is an important modifiable risk factor of coronary heart diseases. Researchers at the Shiraz University of Medical Sciences conducted a randomized, double blind case-control study to evaluate the lipid-lowering effect of Persian walnut oil. Sixty hyperlipidemic subjects were randomized into 2 groups; group A patients received 3 grams per day of walnut oil for 45 days. Group B patients received placebo and served as the control group. Lipid profiles of both groups were checked before; on days 15, 30, and 45 after the beginning; and 15 days after termination of the study. Plasma triglyceride concentrations decreased by 19% to 33% of baseline in group A patients (p value < 0.05). The authors concluded that walnut oil is a good antihypertriglyceridemic natural remedy. (23)

In one study, cuminaldehyde was compared to quercetin as an aldose reductase inhibitor and acarbose as an alpha-glucosidase inhibitor. Cuminaldehyde was shown to have statistically significant but less inhibitory activity than acarbose and quercitin. Thus, the researchers suggest that cuminaldehyde may be useful as a lead compound and a new agent in the treatment of diabetes in combination with traditional therapies. (28)

Black cumin seed oil (CSO) has shown considerable antioxidant and anti-inflammatory activities. Chronic cerebral hypoperfusion has been linked to neurodegenerative disorders including Alzheimer’s disease (AD) and its subsequent cognitive impairment in which oxidative stress and neuroinflammation are the principal culprits. In a 2012 study, subjects were divided into 3 groups: sham control, untreated bilateral common carotid arteries occlusion (CAO) and a CSO treated CAO group. All groups were tested at the tenth postoperative week. Working memory test results for both sham control and CSO treated groups showed significantly improved recall than in the untreated CAO group across several different memory tests. Thus, black cumin seed oil demonstrates noticeable spatial cognitive preservation in subjects challenged with chronic cerebral hypoperfusion, which indicates a promising neuroprotective effect. (29)

Japanese researchers have found that black cumin oil has inhibitory effects on pro-inflammatory arachidonic acid (AA)-induced platelet aggregation and blood coagulation. They then examined the various compounds in black cumin oil via the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis. (30) The steam-distilled oil of Iranian black cumin seed was investigated for its analgesic and anti-inflammatory properties at the Isfahan University of Medical Sciences. Black cumin seed oil (CSO) was found to produce a significant analgesic effect in three different tests. Naloxone, an opioid antagonist, could not reverse the analgesic effect observed in the tests. Although oral administration of CSO at doses of 100, 200 and 400 micro L/kg did not exert a significant anti-inflammatory effect, intraperitoneal injection of the same doses significantly (p < 0.001) inhibited carrageenan-induced oedema. CSO at doses of 10 and 20 micro L/ear also reduced croton oil-induced oedema. It seems that mechanisms other than opioid receptors are involved in the analgesic effect of CSO since naloxone could not reverse this effect. Both systemic and local administration of CSO showed anti-inflammatory activity. Black cumin seed oil may be an important potential intervention in the treatment of chronic pain and inflammatory conditions. (31)

Perilla seed oil contains Rosmarinic acid (RA) which is a natural polyphenolic substance contained in Perilla frutescens. Previous studies have shown rosmarinic acid has antioxidative and anti-inflammatory activity. In a recent study published in the European Journal of Nutrition, Japanese researchers sought to determine the absorption, metabolism, and urinary excretion of RA after intake of perilla extract in healthy humans. The study was performed in a crossover design involving single intakes of perilla extract containing 200 mg RA and placebo with a 10 day interval between treatments. RA, methylated RA, caffeic acid (CAA), ferulic acid (FA), and a trace of m-coumaric acid (COA) were detected in the urine after intake of perilla extract. Thus, RA contained in perilla extract was absorbed, conjugated and methylated following intake, with a small proportion of RA being degraded into various components, such as conjugated forms of CAA, FA and COA. These perilla extract metabolites were then rapidly excreted in the urine, showing that perilla seed oil is both a safe and effective source of the anti-inflammatory antioxidant rosmarinic acid. (35)

Perilla seed oil enriched for rosmarinic acid suppresses allergic immunoglobulin responses and inflammation caused by the white blood cells of the immune system. In a 21-day, randomized, double- blind, age-matched, placebo-controlled parallel group study to determine whether oral supplementation with rosmarinic acid from perilla seed oil is an effective intervention for patients with seasonal allergies, patients with mild allergies were treated daily with extract of perilla seed oil enriched for rosmarinic acid or placebo. Patients recorded symptoms daily in a diary. Profiles of infiltrating white blood cells and concentrations of the inflammatory cytokines eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of perilla seed oil resulted in a significant increase in improvement rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P<0.05). Active treatment significantly decreased the numbers of neutrophil and eosinophil white blood cells in nasal lavage fluid vs. placebo (P<0.05). Patients reported no adverse events, and no abnormalities were detected in routine blood tests. The authors concluded that perilla seed oil enriched with rosmarinic acid could be an effective intervention for mild seasonal allergies at least partly through inhibition of white blood cell infiltration into the nostrils. Thus, use of Membrosia Fluidizer as part of the 2-Step Membrosia Formula may be an effective, low-cost treatment for allergic diseases. (36)

In a recent study from the Department of Pharmacognosy of Kyoto University, the kidney protective effects of perilla were evaluated in subjects that spontaneously develop high levels of serum immunoglobulin A (IgA) along with IgA deposition in the kidney tissue. A perilla extract and its major active constituent, rosmarinic acid (RA), were taken orally for 16 weeks. At the end of the study, the researchers measured protein in the urine and serum IgA levels and generated tissue scores from kidney biopsies. They also measured concentrations of IgA in intestinal Peyer’s patch cells and spleen cells obtained from the subjects. Perilla seed oil suppressed protein in the urine, proliferation of kidney cells, serum levels of IgA, kidney IgA, and IgG deposits. Peyer’s patch cells and spleen cells from perilla-treated subjects produced significantly less IgA than controls. The scientists concluded that perilla seed oil may prevent or even slow down the progression of the deadly IgA nephropathy—an often fatal kidney disease usually requiring a kidney transplant—in part, through modulation of the intestinal mucosal immune system. These effects were caused by perilla oil’s rosmarinic acid acting synergistically with other constituents. (37)

Perilla seed oil has also been shown to be a rich source of the flavone apigenin, famous for its role as the primary anxiolytic and antidepressant constituent in chamomile flower (Matricaria recutita). In a recent study on swimmers, the effects of apigenin from perilla seed oil were evaluated on the central noradrenergic, dopaminergic and serotonergic activities during a stress test. Apigenin significantly decreased the duration of immobility in the swimming stress test. At the highest dose, the duration of immobility was returned to the control level in the test. Apigenin treatment produced attenuation of forced swim test-induced decrease of dopamine turnover in the amygdala and increase of dopamine turnover in the hypothalamus. These behavioral and biochemical results indicate the antidepressant properties of apigenin from perilla seed oil, which may be mediated by the dopaminergic mechanisms in the brain. Thus, the 2-Step Membrosia System may be particularly effective at reducing symptoms of anxiety when combined with our Tranquillity Base formula, another rich source of apigenin. (38)

Cod liver oil.  Since it is a form of fish oil, all of the many benefits of fish oils also apply to cod liver oil. (See also the entry for our Fish Oil Formula for more information.) In addition to the benefits inherent in any fish oil, cod liver oil is one of nature’s richest sources of vitamins A and D, and as such, can be helpful for the majority of people who do not get enough of these vitamins on a daily basis. (44) Both vitamins A and D are involved in the cycles of mineral and hormone balance that help to maintain normal bone formation and density. In addition, Vitamin A is an essential nutrient in maintaining cell membrane integrity, normal vision, and reproduction. (45)

Women with solid tumors have better survival rates if they consumed cod liver oil in the year before they were diagnosed. Researchers at the University of Tromso, Norway used data collected from participants in the Norwegian Women and Cancer study. The study analyzed data on 4,242 women who were diagnosed with their first cancer between the time they completed the questionnaires and the year 2007. The researchers analyzed solid tumor cancers; including lung, colorectal, and breast. The dietary supplement most often used by the Norwegian women was cod liver oil. The women who had taken cod liver oil on a daily basis during the year before they were diagnosed with a solid tumor cancer had a 23 percent lower risk of dying during the period studied than women who never used dietary supplements. Victims of lung cancer especially lowered their risk of death by the use of cod liver oil with an astounding 44 percent lower risk. (46)

Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset Type 1 diabetes. In Norway, cod liver oil is an important source of dietary vitamin D and the long-chain n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid—all of which have biological properties of potential relevance for the prevention of Type 1 diabetes. In a large, population-based, case-control study, the main objective was to investigate whether the use of dietary cod liver oil or other vitamin D supplements, either by the mother during pregnancy or by the child during the first year of life, is associated with a lower risk of Type 1 diabetes in children. The study results showed that the use of cod liver oil in the first year of life was associated with a significantly lower risk of Type 1 diabetes. Cod liver oil consumption by mothers and young children seems to reduce the risk of developing Type 1 diabetes through the anti-inflammatory effects of its long-chain n-3 fatty acids. (47)

Cod liver oil is recommended for the treatment of rheumatoid arthritis. In one study, 43 patients with rheumatoid arthritis ingested cod liver oil daily for 3 months. Decreases occurred in morning stiffness (52%), painful (42%) swollen joints (40%), and pain intensity (67%). Ratings of “good” or “very good” were awarded by 68% of the patients for efficacy and by 95% for tolerability, showing that cod liver oil is both safe and effective in the treatment of rheumatoid arthritis. (48)

In another study at Dundee University in Scotland, researchers found that supplementing with cod liver oil daily reduced the need for non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis (RA) patients by 30%. Volunteers in the study were given either cod liver oil or placebo; and after 12 weeks, asked to gradually reduce their use of NSAIDs, such as ibuprofen. After nine months, 40% of those taking cod liver oil reduced their daily dose of NSAIDs compared with only 10% taking a placebo. This study suggests that cod liver oil supplements can be used as NSAID-sparing agents in RA patients. (49)

Cod liver oil can be helpful alongside daily multivitamins in children for the prevention and treatment of chronic sinusitis. Inflammation and swelling of the sinuses and nasal mucosa are important in the pathophysiology of sinusitis. At the New York Eye and Ear Infirmary in 2004, they performed a 4-month, open-label, dose-titration study; in which each subject served as his own control. Lemon-flavored cod liver oil and a children’s multivitamin-mineral with selenium were prescribed in escalating doses. Subjects were private pediatric otolaryngology outpatients with a clinical diagnosis of chronic/ recurrent sinusitis, whose symptoms were refractory to treatment with antibiotics. Four, six, and eight weeks after beginning the cod liver oil + multivitamin, all of the study participants who remained in the study had decreased sinus symptoms, fewer episodes of acute sinusitis, and fewer doctor visits for acute illnesses. Their parents reported that they had begun to recover from upper respiratory illnesses without complications, which was unusual for these children, as was improvement in springtime; their improvement had previously been limited to the summer months or periods of home-schooling. The study authors concluded that the use of cod liver oil and a multivitamin-mineral with selenium in children with chronic/recurrent sinusitis is an inexpensive, non-invasive intervention that doctors can use for selected patients. (50)

Take the Membrosia Fluidzer along with the Membrosia Complex amd mixed together with a favorite juice to produce a tasty, satisfying smoothie-like drink.

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