C O N T E N T SSee Also
DescriptionOfficial Symbol: UCP2 and Name: uncoupling protein 2 (mitochondrial, proton carrier) Gene type: protein coding Gene name: UCP2 Gene description: uncoupling protein 2 (mitochondrial, proton carrier) Organism: Homo sapiens Gene aliases: UCPH; SLC25A8 Chromosome: 11; Location: 11q13 SummaryMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. DiscussionAbstractsThe emerging functions of UCP2 in health, disease, and therapeuticsAntioxid Redox Signal. 2006 Jan-Feb;8(1-2):1-38. Mattiasson G, Sullivan PG.
Links |